Quality Standard and Detection Method Of Carbomer Copolymer In Chinese Pharmacopoeia. Carbomer copolymer is a long-chain alkyl methacrylate polymer copolymer of acrylic acid bonded polyols with non benzene solvent as polymerization solvent. According to the dry product, the carboxylic acid group (- cooh) shall be 52.0% ~ 62.0%.

Due to the special eye protection mechanism, such as tear flushing, blinking movement, corneal low permeability and many other physiological factors, ordinary eye drops will be quickly eliminated, drug absorption is limited, and the bioavailability after eye administration is restricted. Improving the bioavailability of drugs in ophthalmic preparations mainly depends on the retention time of drugs in the eye (cornea). The longer the time, the greater the amount of drugs absorbed and the better the curative effect. Some dosage forms such as suspension or eye ointment can stay in the eyes, but solid or semi-solid will make the patient uncomfortable. Carbomer gel has good adhesion, non-toxic and non irritant. It can extend the time of action and increase the absorption and utilization of drugs. The study showed that the contact time between Carbomer gel and eye was concentration dependent.

Drug R&D involves a wide range of projects, multiple fields and disciplines, with long R&D cycle, large investment amount and significant complexity. During drug R&D, the listing license holder shall formulate the management system and design the drug test plan according to the actual situation of the enterprise, strictly abide by the system and carry out the test according to the test plan, Truthfully record the experimental data to ensure the authenticity, accuracy and integrity of the application data. In this process, the quality management system is the key. The management level of drug R&D quality has a direct impact on the final quality of drugs. This paper mainly analyzes and discusses the characteristics of drug R&D and summarizes the measures to improve the quality management of drug R&D.